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Severe Asthma

45.00
Product Code: ERM84-MEM-26041PU
  • Edited by Kian Fan Chung, Elliot Israel and Peter G. Gibson
    Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma epidemiology, diagnosis, mechanisms, treatment and management  but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various 'omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

    Contents list 
    1. Definition and impact 
    2. Understanding the experience of people living with severe asthma
    3. The contribution of comorbidities, psychosocial factors and adherence to the presentation of severe asthma
    4. Clinical phenotypes: adults
    5. Clinical phenotypes: children
    6. Mechanisms underlying fixed airflow obstruction and exacerbations
    7. Clinical biomarkers and noninvasive assessment 
    8. Imaging 
    9. Pathophysiology 
    10. The lessons from U-BIOPRED 
    11. SARP: dissecting subphenotypes and endotypes
    12. Molecular phenotypes
    13. Metabolic dysfunction 
    14. Corticosteroid responsiveness and resistance 
    15. Mechanisms in children
    16. Evaluation and management in children
    17. Evaluation of difficult-to-treat and severe asthma in adults
    18. Biologics targeting type 2 inflammation
    19. Nonpharmacological interventions: behavioural and interventional approaches
    20. Management in adults
    21. The next decade of continuing progress

    This book also includes clinical cases

    ISBN 978-1-84984-103-0
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