Obstructive and Central Sleep Apnoea

Edited by Winfried J. Randerath, Jean-Louis Pepin and Sophia E. Schiza
Scientific research of the last decade has substantially transformed our understanding of sleep disordered breathing. This Monograph aims to reflect that change, by providing content that covers the current state of the art, while also charting the future course of sleep medicine. Guest Editors Winfried J. Randerath, Jean-Louis Pepin and Sophia E. Schiza have brought together leading international expert authors to provide chapters on pathophysiology, risk stratification, diagnosis, management and treatment. Opening with a patient perspective chapter, which serves to ground the issue in the reality of patient-centred medicine, the Guest Editors hope that this Monograph will be both a practical clinical guide and an intellectual stimulus, encouraging readers to question established paradigms and embrace the complexity of modern sleep medicine.

Contents list
1. Management of sleep disorders in Europe: a patient's journey

Pathophysiology
2. Obesity, the environment and global warming: current epidemiology and perspectives in modulating the increased burden of sleep disordered breathing by 2050
3. The impact of obesity: obstruction, restriction, inflammation and endocrine function
4. The pathophysiological traits of obstructive sleep apnoea. What do we know? What are we missing?
5. Mechanisms, biomarkers, clinical manifestations and treatment controversies of vascular damage
6. Obstructive sleep apnoea and oncogenesis: what is the evidence?

Heterogeneity of obstructive sleep apnoea and risk stratification
7. The evaluation of patient-reported outcomes
8. Apnoea/hypopnoea index, hypoxia, autonomic arousals, pulse wave and heart rate variability: what matters?
9. Cluster analysis: relevance for phenotyping and outcome
10. Integrative concepts of classification and treatment decision
11. Obstructive sleep apnoea and insomnia 
12. COPD-OSA and IPF-OSA overlap
13. Obesity hypoventilation syndrome: current knowledge and new developments
14. Obstructive sleep apnoea in females

Standards and innovations in diagnosis and management
15. Technological innovation, digital health and artificial intelligence for sleep apnoea diagnosis and treatment follow-up 
16. Wearables, single-channel screening, polygraphy and polysomnography: why, where and how?
17. Multiple-night diagnosis: a revolution in the field?

Treatment of obstructive sleep apnoea
18. Obesity management: behaviour, drugs and surgery
19. Positive airway pressure therapies: indications, selection and management
20. Non-positive airway pressure therapies: from orthodontics to surgery
21. Towards a new era: pharmaceutical treatments and combination therapy

Central sleep apnoea
22. Central sleep apnoea: epidemiology, entities and pathophysiological concepts
23. Diagnostic tools: differentiation of central from obstructive hypopnoeas, and hypercapnic chemoresponsiveness
24. Central sleep apnoea in heart failure: treatment with oxygen, drugs and positive airway pressure

Print ISBN: 978-1-84984-214-3
eISBN: 978-1-84984-215-0
EPUB ISBN: 978-1-84984-216-7